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Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis
Clin Exp Emerg Med. 2023;10(2):157-171.   Published online March 7, 2023
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Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis
Clin Exp Emerg Med. 2023;10(2):157-171.   Published online March 7, 2023
Close
Objective
To evaluate mortality from sepsis and septic shock in Korea during the past 10 years, we conducted a systematic review and meta-analysis.
Methods
We searched six databases for studies on mortality from sepsis and septic shock in adult patients. Primary outcomes were 28- or 30-day mortality and in-hospital mortality from sepsis and septic shock. To assess the risk of bias, we used the Newcastle-Ottawa Scale and Risk of Bias 2 tools. The protocol is registered in PROSPERO (No. CRD42022365739).
Results
A total of 61 studies were included. The mortality rates from sepsis and septic shock at 28 or 30 days were 22.7% (95% confidence interval [CI], 20.0%–25.6%; I2=89%) and 27.6% (95% CI, 22.3%–33.5%; I2=98%), respectively, according to the Sepsis-3 criteria. Furthermore, in accordance with the Sepsis-3 criteria, the in-hospital mortality rates were 28.1% (95% CI, 25.2%–31.1%; I2=87%) and 34.3% (95% CI, 27.2%–42.2%; I2=97%), respectively.
Conclusion
The mortality rates from sepsis and septic shock in Korea are high. In the case of septic shock, the in-hospital mortality rate is approximately 30%.

Citations

Citations to this article as recorded by  Crossref logo
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    Kyung Hun Yoo, Gil Joon Suh, Woon Yong Kwon, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Kyuseok Kim, Yoo Seok Park, Tae Gun Shin, Byuk Sung Ko, Tae Ho Lim, Yongil Cho
    Journal of Korean Medical Science.2026;[Epub]     CrossRef
  • Free Thyroxine as a Predictor of Mortality in Critically Ill Septic Patients—A Retrospective Study
    Matei Florin Negruț, Vlad Pastor, Robert Bolcaș, Oana Antal, Robert Szabo, Cristina Petrișor
    Diagnostics.2026; 16(5): 680.     CrossRef
  • Comparison of prognosis in emergency department elderly septic shock patients with initial hypotension versus delayed hypotension
    Chaeeun Lee, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Tae Ho Lim, Sangchun Choi, Tae Gun Shin, Sangun Nah, Sangsoo Han
    European Journal of Emergency Medicine.2026; 33(3): 169.     CrossRef
  • Clinical Profiles, Interventions, and Outcomes of Sepsis and Septic Shock in a Saudi Arabian Tertiary ICU: A Five-Year Retrospective Analysis
    Amer Asiri, Khaled Abdulwahab Amer, Mushary Alqahtani, Lena A. Almathami, Osama Ayed Asiri, Sultan Saad Alnasser, Ahmed Ali Khuzayyim, Bander Abdullah Alqahtani, Fatimah Mohammed Asiri, Hatem Mostafa Asiri
    Healthcare.2026; 14(5): 680.     CrossRef
  • Papaverine Mitigates Acute Kidney Injury in Feces-Induced Polymicrobial Sepsis Through Regulation of the HMGB1–RAGE Axis
    Mehmet Fatih Dasiran, Ahmet Akbaş, Bakiye Akbaş, Ejder Saylav Bora, Hatice Aygun, Oytun Erbas
    Medicina.2026; 62(4): 621.     CrossRef
  • Knowledge, attitudes, and practices of pre-hospital emergency medical care practitioners regarding sepsis recognition: a cross-sectional study in Qatar
    Michael Steven Paul Lewis, Paula J. W. Smith, Ian Lucas Howard, Hassan Farhat, Guillaume Alinier
    BMC Emergency Medicine.2026;[Epub]     CrossRef
  • Outcomes and risk factors in HIV-positive patients with sepsis: a retrospective study
    Qiang Gao, Tingting Wang, Shun Tan, Yu Tian, An Zhang
    European Journal of Medical Research.2025;[Epub]     CrossRef
  • Prognostic Value of the AST/ALT Ratio in Patients with Septic Shock: A Prospective, Multicenter, Registry-Based Observational Study
    Sungwoo Choi, Sangun Nah, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Tae Ho Lim, Sangchun Choi, Tae Gun Shin, Sangsoo Han
    Diagnostics.2025; 15(14): 1773.     CrossRef
  • Epidemiology and outcomes of septic shock in Japan: a nationwide retrospective cohort study from a medical claims database by the Japan Sepsis Alliance (JaSA) study group
    Taro Imaeda, Takehiko Oami, Tatsuro Yokoyama, Satoshi Nakagawa, Hiroshi Ogura, Nobuaki Shime, Yutaka Umemura, Asako Matsushima, Kiyohide Fushimi, Taka-aki Nakada
    Critical Care.2025;[Epub]     CrossRef
  • Epidemiology of sepsis in emergency departments: insights from the National Emergency Department Information System (NEDIS) database in Korea, 2018–2022
    Tae Gun Shin, Eunsil Ko, So-hyun Han, Taehui Kim, Dai Hai Choi
    Clinical and Experimental Emergency Medicine.2025; 12(3): 185.     CrossRef
  • Predicting septic shock in patients with sepsis at emergency department triage using systolic and diastolic shock index
    Yumin Jeon, Sungjin Kim, Sejoong Ahn, Jong-Hak Park, Hanjin Cho, Sungwoo Moon, Sukyo Lee
    The American Journal of Emergency Medicine.2024; 78: 196.     CrossRef
  • An observational study on the impact of overcrowding towards door-to-antibiotic time among sepsis patients presented to emergency department of a tertiary academic hospital
    Evelyn Yi Wen Chau, Afliza Abu Bakar, Aireen Binti Zamhot, Ida Zarina Zaini, Siti Norafida Binti Adanan, Dazlin Masdiana Binti Sabardin
    BMC Emergency Medicine.2024;[Epub]     CrossRef
  • Ischemia-Modified Albumin, Lactate, and Combination for Predicting Mortality in Patients with Septic Shock in the Emergency Department
    Bo-Yeong Jin, Sukyo Lee, Woosik Kim, Jong-Hak Park, Hanjin Cho, Sungwoo Moon, Sejoong Ahn
    Biomedicines.2024; 12(7): 1421.     CrossRef
  • Temperature trajectories and mortality in hypothermic sepsis patients
    Dongkwan Han, Seung Hyun Kang, Young Woo Um, Hee Eun Kim, Ji Eun Hwang, Jae Hyuk Lee, You Hwan Jo, Yoon Sun Jung, Hui Jai Lee
    The American Journal of Emergency Medicine.2024; 84: 18.     CrossRef
  • Comparison of Early and Late Norepinephrine Administration in Patients With Septic Shock
    Chiwon Ahn, Gina Yu, Tae Gun Shin, Youngsuk Cho, Sunghoon Park, Gee Young Suh
    CHEST.2024; 166(6): 1417.     CrossRef
  • Diagnostic Accuracy of Plasma Renin Concentration and Renin Activity in Predicting Mortality and Kidney Outcomes in Patients With Septic Shock and Hypoperfusion or Hypotension: A Multicenter, Prospective, Observational Study
    Gun Tak Lee, Byuk Sung Ko, Da Seul Kim, Minha Kim, Jong Eun Park, Sung Yeon Hwang, Daun Jeong, Chi Ryang Chung, Hyunggoo Kang, Jaehoon Oh, Tae Ho Lim, Bora Chae, Won Young Kim, Tae Gun Shin
    Annals of Laboratory Medicine.2024; 44(6): 497.     CrossRef
  • The mortality of patients with sepsis increases in the first month of a new academic year
    Sukyo Lee, Sungjin Kim, Sejoong Ahn, Hanjin Cho, Sungwoo Moon, Young Duck Cho, Jong-Hak Park
    Clinical and Experimental Emergency Medicine.2024; 11(2): 161.     CrossRef
  • Efficacy of neutrophil-lymphocyte ratio, serum lactate, and lactate clearance in predicting mortality in patients with sepsis admitted to a tertiary care hospital: A prospective observational study
    Shiv Akshat, Avishek Roy, Vinay Gandhi Mukkelli, Rahul Kumar Anand, Dalim Kumar Baidya, Bikash Ranjan Ray, Manish Soneja, Lokesh Kashyap, Puneet Khanna, Praveen Aggarwal
    Indian Journal of Medical Sciences.2024; 77: 85.     CrossRef
  • Early management of adult sepsis and septic shock: Korean clinical practice guidelines
    Chul Park, Nam Su Ku, Dae Won Park, Joo Hyun Park, Tae Sun Ha, Do Wan Kim, So Young Park, Youjin Chang, Kwang Wook Jo, Moon Seong Baek, Yijun Seo, Tae Gun Shin, Gina Yu, Jongmin Lee, Yong Jun Choi, Ji Young Jang, Yun Tae Jung, Inseok Jeong, Hwa Jin Cho, A
    Acute and Critical Care.2024; 39(4): 445.     CrossRef
  • Nutritional support for sepsis: is there a single concept?
    I.N. Pasechnik, A.A. Shchuchko, M.S. Kurochkin, T.V. Novikova
    Russian Journal of Anesthesiology and Reanimatology.2024; (6): 70.     CrossRef
  • Assessment of organ failure in sepsis patients in the emergency department: clinical evaluation, Sequential Organ Failure Assessment (SOFA) score, and future perspectives
    Tae Gun Shin
    Clinical and Experimental Emergency Medicine.2024; 11(4): 327.     CrossRef
  • Advances in metabolomics in critically ill patients with sepsis and septic shock
    Swarnima Pandey
    Clinical and Experimental Emergency Medicine.2024; 12(1): 4.     CrossRef
  • Hemodynamic management of septic shock: beyond the Surviving Sepsis Campaign guidelines
    Gil Joon Suh, Tae Gun shin, Woon Yong Kwon, Kyuseok Kim, You Hwan Jo, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim
    Clinical and Experimental Emergency Medicine.2023; 10(3): 255.     CrossRef
  • Prognostic accuracy of initial and 24-h maximum SOFA scores of septic shock patients in the emergency department
    Tae Han Kim, Daun Jeong, Jong Eun Park, Sung Yeon Hwang, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Gun Tak Lee, Tae Gun Shin
    Heliyon.2023; 9(9): e19480.     CrossRef
  • The Pattern of Admission, Clinical Characteristics, and Outcomes Among Patients Admitted to the Intensive Care Unit of a Tertiary Hospital in Tanzania: A 5-Year Retrospective Review
    Nadeem Kassam, Philip Adebayo, Iris Matei, Eric Aghan, Samina Somji, Samwel Kadelya, Yasson Abha, Frank Swai, Mangaro Mabusi, Kamran Hameed, Hanifa Mbithe, Alyyah Thawer, Mandela Makakala, Fatma Bakshi, Harrison Chuwa, Masolwa Ng'wanasayi, Casmir Wambura,
    Patient Related Outcome Measures.2023; Volume 14: 383.     CrossRef
  • Modified Cardiovascular Sequential Organ Failure Assessment Score in Sepsis: External Validation in Intensive Care Unit Patients
    Byuk Sung Ko, Seung Mok Ryoo, Eunah Han, Hyunglan Chang, Chang June Yune, Hui Jai Lee, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Tae Ho Lim, Won Young Kim, Jang Won Sohn, Mi Ae Jeong, Sung Yeon Hwang, Tae Gun Shin, Kyuseok Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • 18,783 View
  • 357 Download
  • 28 Web of Science
  • 26 Crossref
Original Articles

Injury & Prevention | Epidemiology

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Trampoline-related injuries in children: a nationwide cross-sectional study in South Korea
Clin Exp Emerg Med. 2020;7(3):190-196.   Published online September 30, 2020
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Trampoline-related injuries in children: a nationwide cross-sectional study in South Korea
Clin Exp Emerg Med. 2020;7(3):190-196.   Published online September 30, 2020
Close
Objective
Trampoline-related injuries have increased in South Korea. However, little research has been conducted on this topic. This study aimed to show the characteristics of pediatric trampoline-related injuries in South Korea and to investigate the factors associated with admission.
Methods
A retrospective, cross-sectional study was conducted using data from South Korea’s Emergency Department-based Injury In-depth Surveillance registry for dates between January 2011 and December 2016. All patients under 18 years of age with trampoline-related injuries were included. We divided the patients into two groups based on whether they were admitted or discharged. Odds ratios with 95% confidence intervals were calculated to evaluate the factors associated with hospital admission for pediatric trampoline-related injuries.
Results
A total of 2,745 patients were enrolled and the incidence increased over time (P for trend<0.01). The most common injury site was the lower extremity (45%). Fracture was the most frequent diagnosis (34.3%). Compared to the discharge group, the adjusted odds ratios (95% confidence intervals) for hospital admission were 3.53 (1.73–7.17) for the teenage group, 2.62 (1.82–3.77) for upper extremity injuries, 18.48 (7.95–42.95) for fractures, 2.28 (1.35–3.86) for falls, and 2.04 (1.15–3.60) for collisions.
Conclusion
Trampoline-related injuries in children have increased over time in South Korea. Most occur in children under the age of 12 years, but children between the ages of 13 and 18 years are at a higher risk for hospitalization. Also, injuries of the upper extremity, fracture, falling, and collision are risk factors for admission. Preventive strategies are needed to reduce trampoline-related injuries in children.

Citations

Citations to this article as recorded by  Crossref logo
  • Outdoor play and risk in kids: a cross-sectional study
    Fiona Armstrong, Michael Barrett, Lorraine D’Arcy, David Gaul
    Archives of Disease in Childhood.2026; 111(3): 205.     CrossRef
  • Trampoline Fractures in Children
    Roope Parviainen, Topi Laaksonen, Petra Grahn, Juha-Jaakko Sinikumpu, Ilkka Helenius, Matti Ahonen
    Journal of Pediatric Orthopaedics.2026;[Epub]     CrossRef
  • Children’s outdoor play injuries: how real are parental concerns of danger in outdoor play?
    Fiona Armstrong, David Gaul
    International Journal of Play.2025; 14(2): 152.     CrossRef
  • Pediatric Trampoline Injuries From Head to Toe
    Neetika Gupta, Hirva Manek, Gali Shapira-Zaltsberg, Kerri Highmore, Elka Miller, Herman Kan
    Roentgen Ray Review.2025;[Epub]     CrossRef
  • A Review of 13,470 Head and Neck Injuries from Trampoline Jumping
    Dani Stanbouly, Rami Stanbouly, Michael Baron, Firat Selvi, Raymond Wong Chung Wen, Sung-Kiang Chuang
    Craniomaxillofacial Trauma & Reconstruction.2024; 17(2): 124.     CrossRef
  • Pediatric Hospitalization Due to Trampoline-Related Injuries in the United States During 2019
    Balagangadhar R Totapally, Ritika Appanagari, Fuad Alkhoury, Keith Meyer
    Cureus.2024;[Epub]     CrossRef
  • Differences in Trampoline-Related Knee Injuries Between Children and Adults: A Cross-Sectional Study
    Martin Husen, Samantha K. Engrav, Dominik Saul, Michael J. Stuart, Todd A. Milbrandt, Bruce A. Levy, Aaron J. Krych, Daniël B.F. Saris
    Orthopaedic Journal of Sports Medicine.2023;[Epub]     CrossRef
  • Trampolining Accidents in an Adult Emergency Department: Analysis of Trampolining Evolution Regarding Severity and Occurrence of Injuries
    Nora Sasse, Mairi Ziaka, Lara Brockhus, Martin Müller, Artistomenis K. Exadaktylos, Jolanta Klukowska-Rötzler
    International Journal of Environmental Research and Public Health.2022; 19(3): 1212.     CrossRef
  • Trampoline Injuries in Children and Adolescents
    Mohammad H. Hussein, Ahmad A. Toreih, Abdallah S. Attia, Majed Alrowaili, Manal S. Fawzy, Danielle Tatum, Eman A. Toraih, Emad Kandil, Juan Duchesne, Sharven Taghavi
    Pediatric Emergency Care.2022; 38(2): e894.     CrossRef
  • Trampoline centre injuries in children and adolescents: a systematic review and meta-analysis
    Carlos Nunez, Guy D Eslick, Elizabeth J Elliott
    Injury Prevention.2022; 28(5): 440.     CrossRef
  • 8,460 View
  • 105 Download
  • 7 Web of Science
  • 10 Crossref

Toxicology | Epidemiology

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Epidemiology and regional differences of acute poisonings of eight cities in Gyeonggi-do province in Korea using data from the National Emergency Department Information System of Korea
Clin Exp Emerg Med. 2020;7(1):43-51.   Published online March 31, 2020
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Epidemiology and regional differences of acute poisonings of eight cities in Gyeonggi-do province in Korea using data from the National Emergency Department Information System of Korea
Clin Exp Emerg Med. 2020;7(1):43-51.   Published online March 31, 2020
Close
Objective
We aimed to analyze the differences in epidemiological aspects and clinical courses of acute poisonings in each region of the Gyeonggi-do province in Korea.

Methods
This retrospective study analyzed data from the National Emergency Department Information System of Korea. We retrospectively reviewed cases of acute poisonings between April 2006 and March 2015 recorded at 13 emergency departments in eight different cities of Gyeonggi-do province in Korea. The differences in the incidence, age distribution, causative agent, and clinical course of poisonings among regions were the main outcomes measured.

Results
The proportion of poisonings in the ≤9 age group was high in Yongin (17.44%) and that in ≥65 age group was high in Gwangmyeong (21.76%). The proportion of cases involving carbon monoxide was high in Ansan (8.82%) in patients hospitalized and the proportion of cases involving pesticides was high in Pyeongtaek (52.78%) in patients admitted to the intensive care unit. The admission rate of poisoned patients was high in Osan (36.02%).

Conclusion
In this study, differences in the characteristics of poisoned patients between 8 cities were noted. Therefore, hospitals need to arrange treatment resources for poisoned patients according to the characteristics of the specific region. The results of this study may serve as evidence for new strategies to prepare for the acute poisonings in hospitals.

Citations

Citations to this article as recorded by  Crossref logo
  • A four-way patient search method for the retrospective identification of poisoning patients
    Veronika Uslin, Ville Hällberg, Timo Lukkarinen, Marjo Niskanen, Teemu Koivistoinen, Ari Palomäki
    Scientific Reports.2024;[Epub]     CrossRef
  • Clinical support system for triage based on federated learning for the Korea triage and acuity scale
    Hansol Chang, Jae Yong Yu, Geun Hyeong Lee, Sejin Heo, Se Uk Lee, Sung Yeon Hwang, Hee Yoon, Won Chul Cha, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Taerim Kim
    Heliyon.2023; 9(8): e19210.     CrossRef
  • Characterization of Acute Poisoning in Hospitalized Children in Southwest China
    Zhu Li, Li Xiao, Lin Yang, Shaojun Li, Liping Tan
    Frontiers in Pediatrics.2021;[Epub]     CrossRef
  • Development of a Mobile Personal Health Record Application Designed for Emergency Care in Korea; Integrated Information from Multicenter Electronic Medical Records
    Yuri Choi, June-sung Kim, In Ho Kwon, Taerim Kim, Su Min Kim, Wonchul Cha, Jinwoo Jeong, Jae-Ho Lee
    Applied Sciences.2020; 10(19): 6711.     CrossRef
  • Frequency and Management of Acute Poisoning Among Children Attending an Emergency Department in Saudi Arabia
    Mansour Tobaiqy, Bandar A. Asiri, Ahmed H. Sholan, Yahya A. Alzahrani, Ayed A. Alkatheeri, Ahmed M. Mahha, Shamsia S. Alzahrani, Katie MacLure
    Pharmacy.2020; 8(4): 189.     CrossRef
  • 8,014 View
  • 122 Download
  • 7 Web of Science
  • 5 Crossref

Resuscitation

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A survey-based study on the protocols for therapeutic hypothermia in cardiac arrest patients in Korea: focusing on the differences between level 1 and 2 centers
Clin Exp Emerg Med. 2015;2(4):210-216.   Published online December 28, 2015
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A survey-based study on the protocols for therapeutic hypothermia in cardiac arrest patients in Korea: focusing on the differences between level 1 and 2 centers
Clin Exp Emerg Med. 2015;2(4):210-216.   Published online December 28, 2015
Close
Objective
We aimed to summarize the therapeutic hypothermia (TH) protocols used in emergency departments (EDs) in Korea and to investigate the differences between level 1 and 2 centers.
Methods
The chief residents from 56 EDs were given a structured survey containing questions on the indications for TH, methods for TH induction, maintaining, and finalizing TH treatments. The participants were divided into 2 groups based on their work place (level 1 vs. level 2 centers).
Results
We received 36 responses to the survey. The majority of the participants (94.4%) reported that they routinely used TH. An average of 5.9 (standard deviation, 3.4) and 3.3 (standard deviation, 2.9) TH procedures were performed monthly in level 1 and 2 centers, respectively (P=0.01). The majority of level 1 and 2 centers (80.0% and 73.1%, respectively) had written TH protocols. Rectal (50.0%) and esophageal probes (38.9%) were most commonly used to monitor the patients’ body temperatures. Midazolam (80.6%) and remifentanyl (47.2%) were the most commonly used sedatives. For TH induction, external cooling devices (77.8%) and cold saline infusion (66.1%) were predominant. Between level 1 and 2 centers, only the number of TH, the usage of remifentanyl, and application of external cooling device showed significant differences (P<0.05)
Conclusion
Our study summarizes the TH protocols used in 36 EDs. The majority of study participants performed TH using a written protocol. We observed small number of differences in TH induction and maintenance methods between level 1 and 2 centers.

Citations

Citations to this article as recorded by  Crossref logo
  • Hypothermia Inhibits Endothelium-Independent Vascular Contractility via Rho-kinase Inhibition
    Yoon Hee Chung, Keon Woong Oh, Sung Tae Kim, Eon Sub Park, Hyun Dong Je, Hyuk-Jun Yoon, Uy Dong Sohn, Ji Hoon Jeong, Hyen-Oh La
    Biomolecules & Therapeutics.2018; 26(2): 139.     CrossRef
  • 23,016 View
  • 81 Download
  • 1 Web of Science
  • 1 Crossref